Pereira P L, Schick F, Einsele H, Farnsworth C T, Kollmansberger C, Mattke A, Duda S H, Claussen C D
Abteilung für Radiologische Diagnostik, Eberhard-Karls-Universität Tübingen.
Rofo. 1999 Mar;170(3):251-7. doi: 10.1055/s-2007-1011036.
Evaluation of MR standard imaging and short time inversion recovery (STIR) imaging to assess changes in red bone marrow cellularity after high-dose chemotherapy (HDC) and peripheral blood stem cells transplantation (PBSCT).
Sixty-one magnetic resonance (MR) studies were performed in 15 patients (8 female and 7 male, average age 45 years) who received HDC and PBSCT for therapy of either a solid tumor or multiple myeloma. All patients underwent MR examinations of the lumbar region and both femora with T1- and T2-weighted turbo spin-echo (TSE) and STIR sequences at predefined time intervals. Qualitative analysis of the signal intensity was performed by consensus reading of four radiologists. MR results were correlated with results of blood smears and marrow histology.
STIR sequences demonstrated marked changes in signal intensity not only until the aplasia occurred but also during bone marrow repopulation. An increased signal intensity was observed after HDC in 13/15 patients (87%), followed by a decrease in signal intensity immediately after aplasia in 14/15 patients (93%). Signal intensity further changed parallel to marrow engraftment in 11/15 patients (73%). T2-TSE only showed clear changes during repopulation in 8/15 patients (53%). The individual course of the signal in T1-TSE was markedly inhomogeneous.
STIR sequences show bone marrow edema during aplasia and marrow cellularity during reconstitution and are suitable for characterisation of red bone marrow after HDC and autologous PBSCT.
评估磁共振（MR）标准成像和短时反转恢复（STIR）成像，以评估大剂量化疗（HDC）和外周血干细胞移植（PBSCT）后红骨髓细胞成分的变化。
对15例（8例女性，7例男性，平均年龄45岁）接受HDC和PBSCT治疗实体瘤或多发性骨髓瘤的患者进行了61次磁共振（MR）检查。所有患者在预定时间间隔接受腰椎和双侧股骨的MR检查，采用T1加权和T2加权快速自旋回波（TSE）序列以及STIR序列。由四位放射科医生共同阅片对信号强度进行定性分析。MR结果与血涂片和骨髓组织学结果相关。
STIR序列不仅在骨髓抑制期，而且在骨髓重建期均显示出信号强度的显著变化。15例患者中有13例（87%）在HDC后观察到信号强度增加，随后15例患者中有14例（93%）在骨髓抑制期后信号强度立即下降。15例患者中有11例（73%）信号强度随着骨髓植入进一步平行变化。T2-TSE仅在15例患者中的8例（53%）重建期显示出明显变化。T1-TSE中信号的个体变化过程明显不均匀。
STIR序列在骨髓抑制期显示骨髓水肿，在重建期显示骨髓细胞成分，适用于HDC和自体PBSCT后红骨髓特征的表征。
