Ingelmo J M, Quereda F, Acién P
Department of Gynecology, Miguel Hernández University, Campus of San Juan, Alicante, Spain.
Fertil Steril. 1999 May;71(5):907-11. doi: 10.1016/s0015-0282(99)00087-4.
To determine the effect of human interferon (IFN)-alpha-2b on experimental endometriosis in rats.
Experimental, controlled, double-blind randomized study.
Experimental surgery laboratory in a university department.
ANIMAL(S): Ninety-six Wistar rats with endometriosis, induced by transplanting four endometrial fragments into the peritoneal cavity.
INTERVENTION(S): One third of the animals served as controls (group A). The others were randomly divided into two groups and were given IFN-alpha-2b either as a single intraperitoneal dose (group B) or as three SC doses (on alternate days) (group C).
MAIN OUTCOME MEASURE(S): Laparotomy was performed to measure the size of each implant at various times (days 0, 6, 12, 20, and 120 after treatment).
RESULT(S): There were no differences among the groups in the size of the average implants before IFN was administered (17.3+/-6.7, 19.7+/-7.8, and 18.1+/-9.2 mm for groups A, B, and C, respectively). These values were significantly smaller after treatment in group B (14.9+/-8.0 mm) and group C (14.0+/-9.5 mm) than in the control group (17.6+/-7.5 mm) (P<.05). Intraperitoneal IFN produced an initial maximum decrease in the size of the implants (40% reduction on day 6), which diminished until day 20 (20%) and then was maintained on a plateau until day 120 (25%). By contrast, group C showed an initial minimal reduction (13% at day 6), which increased up to day 20 (19%), after which a plateau was reached (23% at day 120). Thus, the effects in both treatment groups were similar in the long term.
CONCLUSION(S): Two short regimens of human IFN-alpha-2b reduced the size of experimental endometriosis in rats.
确定人干扰素（IFN）-α-2b对大鼠实验性子宫内膜异位症的影响。
实验性、对照、双盲随机研究。
大学某科室的实验外科实验室。
96只患有子宫内膜异位症的Wistar大鼠，通过将4个子宫内膜碎片移植到腹腔诱导而成。
三分之一的动物作为对照组（A组）。其余动物随机分为两组，分别给予单次腹腔注射IFN-α-2b（B组）或三次皮下注射（隔日注射）（C组）。
在不同时间（治疗后第0、6、12、20和120天）进行剖腹手术以测量每个植入物的大小。
在给予IFN之前，各组平均植入物大小无差异（A组、B组和C组分别为17.3±6.7、19.7±7.8和18.1±9.2mm）。治疗后，B组（14.9±8.0mm）和C组（14.0±9.5mm）的这些值明显小于对照组（17.6±7.5mm）（P<0.05）。腹腔注射IFN使植入物大小最初最大程度减小（第6天减少40%），到第20天减小程度减弱（20%），然后在第120天维持在平台期（25%）。相比之下，C组最初减小程度最小（第6天为13%），到第20天增加至（19%），之后达到平台期（第120天为23%）。因此，从长期来看，两个治疗组的效果相似。
两种短疗程的人IFN-α-2b可减小大鼠实验性子宫内膜异位症的大小。
Zotero 插件