Appleyard Caroline B, Cruz Myrella L, Hernández Siomara, Thompson Kenira J, Bayona Manuel, Flores Idhaliz
Department of Physiology and Pharmacology, Ponce School of Medicine and Health Sciences, Ponce, PR, USA
Department of Physiology and Pharmacology, Ponce School of Medicine and Health Sciences, Ponce, PR, USA.
Reprod Sci. 2015 Apr;22(4):431-41. doi: 10.1177/1933719114542022. Epub 2014 Jul 11.
We have previously shown detrimental effects of stress in an animal model of endometriosis. We now investigated whether the ability to control stress can affect disease parameters. Endometriosis was surgically induced in female Sprague-Dawley rats before exposing animals to a controllable (submerged platform) or uncontrollable (no platform) swim stress protocol. Corticosterone levels and fecal pellet numbers were measured as an indicator of stress. Uncontrollable stress increased the number and size of the endometriotic cysts. Rats receiving uncontrollable stress had higher anxiety than those exposed to controllable stress or no stress and higher corticosterone levels. Uncontrollable stressed rats had more colonic damage and uterine cell infiltration compared to no stress, while controllable stress rats showed less of an effect. Uncontrollable stress also increased both colonic and uterine motility. In summary, the level of stress controllability appears to modulate the behavior and pathophysiology of endometriosis and offers evidence for evaluating therapeutic interventions.
我们之前已在子宫内膜异位症动物模型中证实了应激的有害影响。我们现在研究了控制应激的能力是否会影响疾病参数。在将雌性斯普拉格-道利大鼠暴露于可控（水下平台）或不可控（无平台）游泳应激方案之前，通过手术诱导其患子宫内膜异位症。测量皮质酮水平和粪便颗粒数量作为应激指标。不可控应激增加了子宫内膜异位囊肿的数量和大小。接受不可控应激的大鼠比暴露于可控应激或无应激的大鼠焦虑程度更高，且皮质酮水平更高。与无应激相比，不可控应激大鼠的结肠损伤和子宫细胞浸润更多，而可控应激大鼠的影响较小。不可控应激还增加了结肠和子宫的蠕动。总之，应激可控水平似乎会调节子宫内膜异位症的行为和病理生理学，并为评估治疗干预措施提供了证据。
