Altintas Devrim, Kokcu Arif, Kandemir Bedri, Cetinkaya Mehmet B, Tosun Migraci
Department of Obstetrics and Gynecology, School of Medicine, University of Ondokuz Mayis, Samsun, Turkey.
Fertil Steril. 2008 Aug;90(2):401-5. doi: 10.1016/j.fertnstert.2007.06.057. Epub 2007 Nov 5.
To investigate the efficacy of imiquimod on endometriosis.
Randomized, placebo-controlled, single-blind, experimental study.
Experimental surgery laboratory at a university in Turkey.
ANIMAL(S): Thirty Wistar female rats.
INTERVENTION(S): After the peritoneal implantation of endometrial tissue, rats were randomized to two equal intervention groups: [1] the control group and [2] the imiquimod group. Six weeks later, after implant volume was measured (volume 1) by performing a second laparotomy, imiquimod (10 mg intraperitoneally per rat, 2 times per wk) was administered to the imiquimod group, and saline solution (0.1 mL SC, once per wk), to the control group, for 8 weeks. At the end of the treatment, a third laparotomy was performed to remeasure implant volumes (volume 2), and implants were totally excised for histopathologic examination.
MAIN OUTCOME MEASURE(S): To compare volume 1 and volume 2 within the groups, as well as stromal and glandular tissues between the groups.
RESULT(S): In the imiquimod group, volume 2 was statistically significantly reduced compared with volume 1, whereas there was no significant volume change in the control group. In the imiquimod group, when compared with the control group, both glandular and stromal tissues had statistically significantly lessened.
CONCLUSION(S): Imiquimod was seen to regress significantly both the size and the histological structure of endometriotic implants.
研究咪喹莫特治疗子宫内膜异位症的疗效。
随机、安慰剂对照、单盲实验研究。
土耳其一所大学的实验外科实验室。
30只Wistar雌性大鼠。
将子宫内膜组织植入大鼠腹腔后,将大鼠随机分为两个相等的干预组:[1]对照组和[2]咪喹莫特组。六周后,通过再次剖腹手术测量植入物体积(体积1),向咪喹莫特组大鼠腹腔内注射咪喹莫特(每只大鼠10 mg,每周2次),向对照组大鼠皮下注射生理盐水(0.1 mL,每周1次),持续8周。治疗结束时,进行第三次剖腹手术重新测量植入物体积(体积2),并将植入物全部切除进行组织病理学检查。
比较各组内的体积1和体积2,以及两组间的间质组织和腺组织。
在咪喹莫特组中,体积2与体积1相比有统计学意义的显著减小,而对照组体积无显著变化。与对照组相比,咪喹莫特组的腺组织和间质组织均有统计学意义的显著减少。
咪喹莫特可使子宫内膜异位症植入物的大小和组织结构显著消退。