Verhagen M A, Roelofs J M, Edelbroek M A, Smout A J, Akkermans L M
Gastrointestinal Motility Unit, University Hospital, Utrecht, The Netherlands.
Aliment Pharmacol Ther. 1999 May;13(5):621-30. doi: 10.1046/j.1365-2036.1999.00520.x.
To investigate the effect of the prokinetic drug, cisapride, on fasting and postprandial acid exposure in the proximal duodenum.
Using a double-blind, placebo-controlled crossover study design, 12 healthy male volunteers were studied. After 1 week of dosing (cisapride 20 mg b.d. orally or placebo), fasting and postprandial antroduodenal pH-and pressure-recordings were made. Using a small-caliber (4 mm) catheter, containing one antral and two duodenal pH electrodes, and two antral and three duodenal pressure recording sites. Transmucosal potential difference was measured to ensure proper catheter position. Infusions of 0.1 N HCl were given in the duodenal bulb.
Endogenous acidification of the duodenal bulb occurred more frequently during phase II and postprandially, compared to phase I (P<0.001). During phase I, alkalinization of the antrum was observed. Cisapride significantly increased the postprandial number of duodenal acidic periods (P<0.02), but shortened their duration (P<0.04). The duodenal motor response elicited by exogenous acid was lower during phase I (P<0.05).
Antral and proximal duodenal acidity vary with the phases of the interdigestive motor complex. Cisapride shortens the individual periods of duodenal acidification.
研究促动力药物西沙必利对十二指肠近端空腹及餐后酸暴露的影响。
采用双盲、安慰剂对照交叉研究设计，对12名健康男性志愿者进行研究。给药1周（口服西沙必利20mg，每日2次或安慰剂）后，进行空腹及餐后胃十二指肠pH值和压力记录。使用一根小口径（4mm）导管，其包含一个胃窦pH电极、两个十二指肠pH电极以及两个胃窦压力记录位点和三个十二指肠压力记录位点。测量跨黏膜电位差以确保导管位置正确。向十二指肠球部输注0.1N盐酸。
与I期相比，十二指肠球部内源性酸化在II期及餐后更频繁发生（P<0.001）。在I期，观察到胃窦碱化。西沙必利显著增加餐后十二指肠酸性期的次数（P<0.02），但缩短了其持续时间（P<0.04）。I期外源性酸引起的十二指肠运动反应较低（P<0.05）。
胃窦和十二指肠近端酸度随消化间期运动复合波的阶段而变化。西沙必利缩短十二指肠酸化的各个时期。
