糖尿病患者β-肾上腺素能受体介导的静脉扩张受损。
Impaired beta-adrenoceptor mediated venodilation in patients with diabetes mellitus.
作者信息
Harada K, Ohmori M, Kitoh Y, Sugimoto K, Fujimura A
机构信息
Department of Clinical Pharmacology, Jichi Medical School, Minamikawachi, Tochigi 329-0498, Japan.
出版信息
Br J Clin Pharmacol. 1999 Apr;47(4):427-31. doi: 10.1046/j.1365-2125.1999.00915.x.
AIMS
We investigated whether venoconstriction by alpha-adrenoceptor stimulation, and venodilation by beta-adrenoceptor stimulation and nitroglycerin are altered in patients with diabetes mellitus (DM).
METHODS
Eight male patients with non insulin-dependent DM and eight age-matched control subjects were included. The patients had neither hypertension nor hyperlipidaemia. Noradrenaline (1 to 512 ng min-1 ), isoprenaline (1 to 256 ng min-1 ) and nitroglycerin (0.5 to 128 ng min-1 ) were infused into a dorsal hand vein and its diameter was measured using a linear variable differential transformer.
RESULTS
The venoconstricting response to noradrenaline and the venodilating response to nitroglycerin in DM patients were similar to those in control subjects, while the venodilation by isoprenaline was significantly (P<0.05) smaller in DM patients than in control subjects at the dose of 32 ng min-1 or more [32 ng min-1: 11.5% vs 29.8% (DM vs control subjects), 64 ng min-1: 19.0% vs 40.1%, 128 ng min-1: 25.2% vs 49.0%, 256 ng min-1: 34.3% vs 56.7%].
CONCLUSIONS
These data suggested that venoconstriction by alpha-adrenoceptor stimulation and venodilation by nitroglycerin are not altered, whereas venodilation by beta-adrenoceptor stimulation might be impaired in patients with DM.
目的
我们研究了糖尿病（DM）患者中α-肾上腺素能受体刺激引起的静脉收缩以及β-肾上腺素能受体刺激和硝酸甘油引起的静脉舒张是否发生改变。
方法
纳入8名非胰岛素依赖型DM男性患者和8名年龄匹配的对照受试者。这些患者既无高血压也无高脂血症。将去甲肾上腺素（1至512 ng·min⁻¹）、异丙肾上腺素（1至256 ng·min⁻¹）和硝酸甘油（0.5至128 ng·min⁻¹）注入手背静脉，并使用线性可变差动变压器测量其直径。
结果
DM患者对去甲肾上腺素的静脉收缩反应和对硝酸甘油的静脉舒张反应与对照受试者相似，而在剂量为32 ng·min⁻¹或更高时，DM患者中异丙肾上腺素引起的静脉舒张明显（P<0.05）小于对照受试者[32 ng·min⁻¹：11.5%对29.8%（DM对对照受试者），64 ng·min⁻¹：19.0%对40.1%，128 ng·min⁻¹：25.2%对49.0%，256 ng·min⁻¹：34.3%对56.7%]。
结论
这些数据表明，α-肾上腺素能受体刺激引起的静脉收缩和硝酸甘油引起的静脉舒张未发生改变，而β-肾上腺素能受体刺激引起的静脉舒张在DM患者中可能受损。
Zotero 插件