Burge S
Dermatology Department, The Churchill, Oxford Radcliffe Hospital, UK.
Clin Exp Dermatol. 1999 Mar;24(2):53-6. doi: 10.1046/j.1365-2230.1999.00416.x.
Darier's disease is an uncommon inherited cutaneous disease which is difficult to manage, especially in adolescence. The warty keratotic papules irritate, smell and look unsightly. Histologically, the condition is characterized by the presence of focal acantholytic dyskeratosis. Treatment is unsatisfactory, particularly in patients with erosive flexural disease, but retinoids reduce the hyperkeratosis. Now the mutation causing Darier's disease has been identified, there is a real possibility of more effective treatment in the future.
毛囊角化病是一种罕见的遗传性皮肤病，难以治疗，在青春期尤为如此。疣状角化丘疹会引起不适，有异味且外观难看。组织学上，该病的特征是存在局灶性棘层松解性角化不良。治疗效果不尽人意，尤其是对于有糜烂性屈侧病变的患者，但维甲酸可减轻角化过度。现在已经确定了导致毛囊角化病的突变，未来很有可能会有更有效的治疗方法。
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