Schmitt L, Roos S, Raulin C, Karsai S
Laserklinik Karlsruhe, Kaiserstrasse 104, 76133, Karlsruhe, Deutschland.
Hautarzt. 2009 Dec;60(12):995-8. doi: 10.1007/s00105-009-1732-2.
Darier disease is often associated with pruritus and an unpleasant odor, causing medical and emotional problems. Ablative laser therapy has proven effective in ameliorating these symptoms. Side effects of this approach include permanent hypopigmentation and a risk of scarring. We present two cases where non-ablative therapy with pulsed dye lasers proved a safe and effective way to manage the intertriginous lesions. Although the mechanism of action is unclear, our success indicates that pulsed dye laser therapy is an option in Darier disease. Larger numbers of patients, ideally in multicenter studies, must be treated in this way to confirm our results.
达里埃病常伴有瘙痒和难闻气味,会引发医学和情感问题。剥脱性激光疗法已被证明能有效改善这些症状。这种方法的副作用包括永久性色素减退和瘢痕形成风险。我们展示了两例病例,其中脉冲染料激光非剥脱性治疗被证明是处理间擦疹病变的一种安全有效的方法。尽管作用机制尚不清楚,但我们的成功表明脉冲染料激光治疗是达里埃病的一种治疗选择。必须以这种方式治疗更多患者,理想情况下是在多中心研究中,以证实我们的结果。