[Role of destruction products of tissue macrophages in regulating granulocytopoiesis].

Peripheral blood leukocytosis and an increase of mature forms of neutrophils and monocytes in the bone marrow, as well as an improvement of the oxygen supply of the bone marrow cells (by the data of polarographic studies) followed the intraperitoneal injections of rat peritoneal macrophage destruction products (MDP) to the recipient rats. Analogous changes were obtained in the bone marrow in case of intraperitoneal injection of the cytotoxic quartz dust particles. Having been injected intraperitoneally to donor CBA mice, the MDPs strikingly stimulated the glanulocytopoietic colonies formation in the spleen of the recipient CBA mice X-irradiated with a lethal dose and then injected intravenously with the bone marrow of spleen tissue suspensions obtained from the donors. The results obtained are discussed from the aspect of a possible role of the destroyed tissue macrophages in the formation of a colony-stimulating factor in the auto-control of the phagocytic responses.