用氯喹对恒河猴输卵管进行化学闭塞

Chemical occlusion of rhesus monkey oviducts with chloroquine.

作者信息

Chandra H, Nigam S C, Zutshi S, Malaviya B

出版信息

Contraception. 1978 Sep;18(3):233-8. doi: 10.1016/s0010-7824(78)80017-1.

Abstract

Fertility control through chemical occlusion of the oviducts with chloroquine was investigated in rhesus monkeys (M.m.). Chloroquine was instilled retrograde through the tubal ostium after laparotomising the monkeys as a 10, 50 and 100% suspension (w/v) in aqueous carboxymethyl cellulose (CMC) solution which was used as a carrier vehicle. Complete occlusion of the Fallopian tubes at the uterotubal junction and also the intramural portions resulted in 15 days after a single instillation.

摘要

在恒河猴（M.m.）中研究了用氯喹通过输卵管化学闭塞来控制生育。在对猴子进行剖腹手术后，将氯喹作为10%、50%和100%（重量/体积）的悬浮液通过输卵管口逆行注入，该悬浮液以羧甲基纤维素（CMC）水溶液作为载体。单次注入后15天，输卵管在子宫输卵管交界处以及壁内部位完全闭塞。