van den Ingh T S, Zwart D, Schotman A J, van Miert A S, Veenendaal G H
Res Vet Sci. 1976 Nov;21(3):264-70.
Acute and chronic forms of disease can be distinguished in Trypanosoma vivax infection in the goat. The main difference between the acute and chronic form seems to be the presence of microthrombi in the acute stage of infection; these consist of platelets, trypanosomes, monocytoid cells and some fibrin. This thrombus formation seems directly related to the high parasitaemia in acute trypanosomiasis and may result in ischaemia which could also explain the haemorrhages, the oedema of the lungs and other tissues, and the necrotic changes found in several organs. The anaemia, associated with erythrophagocytosis, haemosiderosis, extramedullary haemopoiesis and hyperactivity of the bone marrow, seemed to be of haemolytic origin. The factors leading to emaciation seemed to be degenerative atrophy of muscular tissue and loss of protein in the urine caused by a possible immune complex glomerulonephritis.
在山羊感染活跃锥虫病时，可区分出急性和慢性疾病形式。急性和慢性形式之间的主要区别似乎在于感染急性期存在微血栓；这些微血栓由血小板、锥虫、单核细胞样细胞和一些纤维蛋白组成。这种血栓形成似乎与急性锥虫病的高寄生虫血症直接相关，可能导致局部缺血，这也可以解释出血、肺和其他组织的水肿以及在几个器官中发现的坏死变化。与红细胞吞噬作用、含铁血黄素沉着、髓外造血和骨髓活动亢进相关的贫血似乎是溶血性的。导致消瘦的因素似乎是肌肉组织的退行性萎缩以及可能由免疫复合物肾小球肾炎引起的尿中蛋白质流失。
