Isoun T T
Acta Trop. 1975;32(3):267-72.
An acute form of trypanosomiasis (course of disease 4 to 8 days) was produced in mice experimentally infected with a strain of T. vivax. The features of the disease were: a parasitemia which appeared to increase exponentially from 23.8 to 243.6 times 10(6) trypanosomes per ml within the last 24 hours of the disease; anaemia was not severe in the disease in mice; the basic histological lesion was generalized fibrin thrombus formation in the blood vessels of the heart, lung, spleen and brain; trypanosome enboli were present in the brain, spleen and liver of infected mice. The disease in mice could prove a useful model in studies of the pathogenesis of acute trypanosomiasis and also in studies in the mechanism of generalized intravascular coagulation.
用一株活跃锥虫实验感染小鼠，使其患上一种急性形式的锥虫病（病程为4至8天）。该病的特征为：在疾病的最后24小时内，寄生虫血症似乎呈指数增长，从每毫升23.8×10⁶增至243.6×10⁶个锥虫；小鼠所患疾病中的贫血并不严重；基本组织学病变为心脏、肺、脾脏和大脑血管中普遍形成纤维蛋白血栓；感染小鼠的大脑、脾脏和肝脏中存在锥虫栓子。小鼠所患疾病可能成为研究急性锥虫病发病机制以及全身性血管内凝血机制的有用模型。
