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氯化甲基蛋氨酸(维生素U)的抗炎作用

[Anti-inflammatory effect of methylmethionine sulfonium chloride (vitamin U)].

作者信息

Urazaeva L G

出版信息

Farmakol Toksikol. 1976 May-Jun;39(3):316-9.

PMID:1026515
Abstract

Tests conducted on mice demonstrated that methylmethionine-sulfonium chloride (vitamin U) is capable of lowering the permeability of the skin capillaries following the action of stimulants. It greatly potentiates the antiphlogistic effect of acetylsalicylic acid, this action being more pronounced with vitamin U administered one hour before intake of acetlsaliclic acid than when both are taken simultaneously. Given in a dose of 1000 mg/kg vitamin U helps reduce exudation in aseptic serosites in rats. The antiphlogistic effect of vitamin U comes in conjunction with its ability to exercise a protective action against lesion of the gastric mucosa produced by acetylsalicylic acid.

摘要

对小鼠进行的试验表明,氯化甲基蛋氨酸(维生素U)在兴奋剂作用后能够降低皮肤毛细血管的通透性。它能大大增强乙酰水杨酸的抗炎作用,在摄入乙酰水杨酸前一小时给予维生素U时,这种作用比两者同时服用时更为明显。以1000毫克/千克的剂量给予维生素U有助于减少大鼠无菌性浆膜炎中的渗出。维生素U的抗炎作用与其对乙酰水杨酸所致胃黏膜损伤的保护作用相关。

相似文献

1
[Anti-inflammatory effect of methylmethionine sulfonium chloride (vitamin U)].氯化甲基蛋氨酸(维生素U)的抗炎作用
Farmakol Toksikol. 1976 May-Jun;39(3):316-9.
2
Effects of S-methylmethionine (vitamin U) on experimental nephrotic hyperlipidemia.S-甲基蛋氨酸(维生素U)对实验性肾病性高脂血症的影响。
Arzneimittelforschung. 1979;29(10):1517-20.
3
Effects of combination treatment with famotidine and methylmethionine sulfonium chloride on the mucus barrier of rat gastric mucosa.法莫替丁与氯化甲基蛋氨酸联合治疗对大鼠胃黏膜黏液屏障的影响。
J Gastroenterol Hepatol. 2009 Mar;24(3):488-92. doi: 10.1111/j.1440-1746.2008.05667.x. Epub 2008 Nov 3.
4
Normalizing effects of S-methylmethionine (vitamin U) on lipoprotein disorder in rats.
Arzneimittelforschung. 1979;29(11):1722-3.
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Hypolipidemic effects of S-methylmethionine (vitamin U) using various experimental procedures.
Arzneimittelforschung. 1980;30(10):1694-703.
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[Treatment of depressive conditions with S-methylmethionine (vitamin U)].
Zh Nevropatol Psikhiatr Im S S Korsakova. 1981;81(8):1209-12.
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[Radiation-protective effect of S-methylmethionine (vitamin U)].
Prikl Biokhim Mikrobiol. 1996 Nov-Dec;32(6):666-8.
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Hypolipidemic effect of L-form S-methylmethionine sulfonium chloride in man.
Arzneimittelforschung. 1981;31(4):725-9.
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Effects of Zn(II) complex with vitamins C and U, and carnitine on metabolic syndrome model rats.维生素 C 和 U 与锌(II)配合物及肉碱对代谢综合征模型大鼠的影响。
Metallomics. 2011 Jul;3(7):683-5. doi: 10.1039/c1mt00018g. Epub 2011 Jun 24.
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Hypolipidemic effects of S-methylmethionine (vitamin U) using various experimental procedures.
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The Photoprotective Effect of S-Methylmethionine Sulfonium in Skin.S-甲基蛋氨酸锍在皮肤中的光保护作用。
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