Seri K, Amemiya K, Sugimoto H, Kato T
Arzneimittelforschung. 1979;29(10):1517-20.
The effects of S-methylmethionine sulfonium chloride (MMSC, vitamin U) on aminonucleoside-induced nephrotic hyperlipidemia in rats were investigated. We found that repeated oral administration of MMSC (dose: daily 1000 mg/kg) exhibited significant amelioration of plasma chloresterol and phospholipids levels. Also, the treatment improved nephrotic syndrome itself by producing an increase of urinary volume and a decrease of urinary protein excretion. The results suggest that MMSC may be useful as single or combined therapy for human nephrotic syndrome and its related hyperlipidemia as a safety drug.
研究了氯化S-甲基蛋氨酸锍（MMSC，维生素U）对氨基核苷诱导的大鼠肾病性高脂血症的影响。我们发现，重复口服MMSC（剂量：每日1000 mg/kg）可显著改善血浆胆固醇和磷脂水平。此外，该治疗通过增加尿量和减少尿蛋白排泄改善了肾病综合征本身。结果表明，MMSC作为一种安全药物，可能对人类肾病综合征及其相关高脂血症的单一或联合治疗有用。
