Neverova M E, Polunovskiĭ V A, Khrushchov N G
Ontogenez. 1976;7(5):475-83.
The heterokaryons of undifferentiated mouse fibroblasts (L and 3T3-4E/TK-) and various cell elements of the rat peritoneal exudate were obtained under the treatment with inactivated Sendai virus. The reactivation of RNA and DNA synthesis in the nuclei of highly differentiated periotoneal exudate cells and the synthesis of thymidine kinase controlled by the nuclei of peritoneal exudate cells were shown to occur in the heterokaryons. During the process of reactivation, the ring-like nuclei of polymorphonuclear leucocytes acquired the form characteristic of the reactivated nuclei of mononuclears. The morphological changes of heparin-containing granules in the cytoplasm of the heterokaryons of mast cells and undifferentiated fibroblasts suggest the degeneration and breakdown of granules.
在经灭活仙台病毒处理的情况下，获得了未分化小鼠成纤维细胞（L和3T3 - 4E/TK -）与大鼠腹腔渗出液各种细胞成分的异核体。结果显示，在这些异核体中，高度分化的腹腔渗出液细胞核内RNA和DNA合成的重新激活以及由腹腔渗出液细胞核控制的胸苷激酶的合成均会发生。在重新激活过程中，多形核白细胞的环状核获得了单核细胞重新激活核的特征形态。肥大细胞与未分化成纤维细胞异核体细胞质中含肝素颗粒的形态变化表明颗粒发生了退化和崩解。
