甲苯咪唑和噻嘧啶双羟萘酸盐作为广谱驱虫药。

Mebendazole and pyrantel pamoate as broad-spectrum anthelmintics.

作者信息

Islam N, Chowdhury N A

出版信息

Southeast Asian J Trop Med Public Health. 1976 Mar(1):81-4.

Abstract

The efficacy of mebendazole and pyrantel pamoate was studied in two groups of 59 and 58 cases, respectively, of patients with polyparasitosis. Mebendazole had a cure rate of 96%, 82.2%, 71.4% and 66.6% in A. lumbricoides, hookworm, T. trichiura and S. stercoralis, respectively, while the corresponding figures for pyrantel pamoate were 92.6%, 85.7%, 19.4% and 0%. Pyrantel pamoate is considered to have no significant effect on T. trichiura and S. stercoralis. None of the drugs had any effect on T. saginata. Both drugs have been found to be equally effective against enterobiasis by various authors. It is recommended that pyrantel pamoate be the drug of choice in cases of multiple parasitic infections excluding T. trichiura and S. stercoralis whereas those with one or both of these in addition to others should be treated with mebendazole. Mebendazole can be prescribed for patients with clinical evidence of helminthic infections even where stool examination is not possible as it covers almost the whole range of common helminthic infections. The only limitation for poorer patients however is its cost. Pyrantel pamoate has a wider applicability for the poorer patients in spite of the fact that it is ineffective against trichurids and S. stercoralis.

摘要

对两组分别为59例和58例多寄生虫感染患者研究了甲苯达唑和噻嘧啶的疗效。甲苯达唑对蛔虫、钩虫、鞭虫和粪类圆线虫的治愈率分别为96%、82.2%、71.4%和66.6%，而噻嘧啶的相应数字分别为92.6%、85.7%、19.4%和0%。噻嘧啶被认为对鞭虫和粪类圆线虫无显著疗效。两种药物对牛带绦虫均无作用。不同作者发现两种药物对蛲虫病同样有效。建议在不包括鞭虫和粪类圆线虫的多重寄生虫感染病例中，噻嘧啶为首选药物，而除其他寄生虫外还伴有鞭虫和（或）粪类圆线虫感染的患者应以甲苯达唑治疗。即使在无法进行粪便检查的情况下，对于有蠕虫感染临床证据的患者也可开具甲苯达唑，因为它几乎涵盖了所有常见的蠕虫感染。然而，对于较贫困患者的唯一限制是其费用。尽管噻嘧啶对鞭虫和粪类圆线虫无效，但它对较贫困患者具有更广泛的适用性。