孟加拉国巴里萨尔医院患者蠕虫感染的发病率以及噻嘧啶与左旋咪唑和甲苯咪唑的对比研究。

Incidence of helminthic infections and comparative study of pyrantel pamoate with levamisole and mebendazole in hospital patients at Barisal, Bangladesh.

作者信息

Islam A F, Sadeque M, Biswas K, Ahmed N, Mahmood G

出版信息

Bangladesh Med Res Counc Bull. 1984 Jun;10(1):29-36.

Abstract

A study was carried out to find out the incidence of helminthic infections in hospitalized patients at Sher-e-Bangla Medical College, Barisal and to determine the comparative efficacy of pyrantel pamoate, levamisole, and mebendazole. It was observed that 76.2 per cent of total hospitalized patients were infected with intestinal helminths. Polyparasitism (52.6 per cent) was more frequent than single infection (21.8 per cent). Amongst these, 47.5 per cent was suffering from Asearis lumbricoides (AL), 42.5 per cent from Hookworm (H.W) and 65.8 per cent from trichuris trichura (TT). Out of 255 cases examined separately, 40 per cent was suffering from Enterobious vermicularis (EV) infection. The comparative study showed that mebendazole produced egg negative stool in 90.9 per cent of AL, 95.6 per cent of HW and 86.8 per cent of TT after eight days of treatment. On the other hand, pyrantel pamoate cured AL in 93.3 per cent, HW in 78.5 per cent and TT in 34.2 per cent eases. Levamisole cured 75 per cent AL, 4.1 per cent H.W. and 22.2 per cent TT within the same period.

摘要

一项研究旨在查明巴里萨尔谢赫·班加拉医学院住院患者的蠕虫感染发生率，并确定噻嘧啶、左旋咪唑和甲苯达唑的相对疗效。据观察，76.2%的住院患者感染了肠道蠕虫。多重寄生虫感染（52.6%）比单一感染（21.8%）更为常见。其中，47.5%的患者感染蛔虫（AL），42.5%感染钩虫（H.W），65.8%感染鞭虫（TT）。在单独检查的255例病例中，40%的患者感染蛲虫（EV）。对比研究表明，治疗八天后，甲苯达唑使90.9%的蛔虫、95.6%的钩虫和86.8%的鞭虫患者粪便虫卵转阴。另一方面，噻嘧啶治愈蛔虫的比例为93.3%，钩虫为78.5%，鞭虫为34.2%。同期，左旋咪唑治愈蛔虫的比例为75%，钩虫为4.1%，鞭虫为22.2%。