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[正常及病理改变关节软骨的糖胺聚糖]

[Glycosaminoglycans of normal and pathologically altered articular cartilage].

作者信息

Iusipova N A, Kostiuk V P, Balesnaia A N, Mamontova V A

出版信息

Vopr Med Khim. 1976 Jul-Aug;22(4):507-13.

PMID:1027236
Abstract

Glycosaminoglycans of tegmental cartilage of human caput femoris were separated into the fractions, which were identified as keratosulfate, hyaluronic acid, heparitin sulphate, chondroitin-4-sulphate, chondroitin-6-sulphate, dermatan sulphate and heparin. Content of glycosaminoglycans in articular cartilage of healthy persons and patients with deforming arthrosis was determined. Content of sulphatated polysaccharides (dermatan sulphate, chondroitin-6-sulphate, keratosulfate and heparitin sulphate) was shown to be distinctly decreased in the cartilage of the patients as compared with the amount of the polysaccharides in the same tissue of healthy persons.

摘要

人股骨头被覆软骨的糖胺聚糖被分离成不同组分,分别鉴定为硫酸角质素、透明质酸、硫酸乙酰肝素、硫酸软骨素-4、硫酸软骨素-6、硫酸皮肤素和肝素。测定了健康人和变形性关节病患者关节软骨中糖胺聚糖的含量。结果显示,与健康人相同组织中的多糖量相比,患者软骨中硫酸化多糖(硫酸皮肤素、硫酸软骨素-6、硫酸角质素和硫酸乙酰肝素)的含量明显降低。

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