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[烧伤所致应激状态下大鼠肝脏和脾脏中蛋白质合成系统的活性及RNA合成]

[Activity of protein-synthesizing system and RNA synthesis in the liver and spleen of rats in stress caused by burns].

作者信息

Abakumova O Iu, Kutsenko N G

出版信息

Vopr Med Khim. 1976 Nov-Dec;22(6):826-30.

PMID:1027255
Abstract

Period of decreased protein synthesis was observed in rats within first hours, after burns but later on the synthesis was distinctly increased in liver and spleen tissues. This increase was apparently due to induction of RNA synthesis as actinomycin D removed the effect of burns on the protein synthesis. Immediately after the burns incorporation of 14C-orotic acid into rapidly-lebelling RNA of rat liver tissue was increased; the increased RNA synthesis was observed and at the 3-rd day after burns.

摘要

在烧伤后的最初几个小时内,观察到大鼠体内蛋白质合成减少,但随后肝脏和脾脏组织中的合成明显增加。这种增加显然是由于RNA合成的诱导,因为放线菌素D消除了烧伤对蛋白质合成的影响。烧伤后立即观察到大鼠肝脏组织中14C-乳清酸掺入快速标记RNA增加;在烧伤后第3天也观察到RNA合成增加。

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