Vasilenko V T, Postnikov A A
Arkh Patol. 1976;38(9):15-20.
The article discusses results of the morphological study of xenografts of the pig's valves fixed in 0.32% and 4% solution of formaldehyde which remained in the human heart during the period ranging from 21 months to several hours. In the xenovalves there occurred progressive destructive changes in their connective-tissue basis, which led to weakening of the mechanical strength and to rupture of the cusps. In the majority of cases, no morphological signs of immune or nonspecific inflammatory cellular reaction were observed. The authors hold that polycondensation of protein molecules occurring in the course of preservation under the effect of formaldehyde, and formation of "superstrong" structures at the expense of increased number of transversal connections between collagenous fibres not always could ensure sufficient mechanical strength of the cusps of the graft.
本文讨论了猪瓣膜异种移植物的形态学研究结果，这些移植物固定在0.32%和4%的甲醛溶液中，在人体心脏中留存的时间从21个月到数小时不等。在异种瓣膜中，其结缔组织基质发生了进行性破坏，导致机械强度减弱和瓣叶破裂。在大多数情况下，未观察到免疫或非特异性炎症细胞反应的形态学迹象。作者认为，在甲醛作用下保存过程中发生的蛋白质分子缩聚，以及以胶原纤维之间横向连接数量增加为代价形成的“超强”结构，并不总能确保移植物瓣叶有足够的机械强度。
