Kondriatiuk V A
Farmakol Toksikol. 1976 Jun-Aug;39(4):470-4.
In experiments with albino male rats the effect of a single introduction into the stomach of methaphos in doses of DL50, 1/10 DL50, 1/20 DL50, 1/50 DL50 and also of a daily consumption of the compound for a month was studied. Metaphos was found to exert a manysided action on the cholopoietic function of the liver, viz. it increases the intensity of the bile secretion, inhibits the synthesis of primary bile acids and conjugation of cholic acid with taurine and glycine, stimulates the formation, conjugation and secretion of bilirubin.
在对白化雄性大鼠进行的实验中，研究了一次性给胃内注入剂量为半数致死量（DL50）、1/10 DL50、1/20 DL50、1/50 DL50的甲基对硫磷的效果，以及连续一个月每日摄入该化合物的效果。发现甲基对硫磷对肝脏的胆汁生成功能有多方面作用，即它会增加胆汁分泌强度，抑制初级胆汁酸的合成以及胆酸与牛磺酸和甘氨酸的结合，刺激胆红素的形成、结合及分泌。
