Skakun L N
Farmakol Toksikol. 1978 Jun-Aug;41(4):465-9.
Experiments set up on albino rats evidenced that 30-day hypokinesia changes the reaction of the liver to cholagogues. In particular, the degree of the choleretic action of oxaphenamide as well as of its inhibitory affect on the synthesis of bile acids diminshes, while the influence on the bilirubin secretion -- increases. In hypokinesia syreper, inhibits biliation, but stimulates the secretion of bilirubin. Owing to a reduced secretion of cholesterol the cholesterol-stablizing properties of the bile improve.
在白化大鼠身上进行的实验证明,30天的运动不足会改变肝脏对利胆剂的反应。特别是,奥沙苯酰胺的利胆作用程度及其对胆汁酸合成的抑制作用减弱,而对胆红素分泌的影响——增强。在运动不足的情况下,西瑞普抑制胆汁分泌,但刺激胆红素分泌。由于胆固醇分泌减少,胆汁的胆固醇稳定特性得到改善。