Kul'minskaia A S, Gazarian K G
Ontogenez. 1976;7(6):590-7.
The erythropoiesis during anemia is characterized by the reduction of the bone marrow period of cell development. Two immature forms, absent in the normal state, were shown to be present under anemia: basophilic erythroblasts and reticulocytes with basophilic cytoplasm. These forms are interposed between the bone marrow basophilic erythroblasts and erythrocytes. Some basophilic erythroblasts turn out in the peripheral blood and transform into basophilic reticulocytes there. The level of transcription in anemic animals during the transformation of basophilic erythroblasts into basophilic reticulocytes does not decrease and is higher than that in polychromatophilic erythroblasts. The total chromatin condensation does not reflect the decrease of the transcription level.
贫血期间的红细胞生成以骨髓细胞发育周期缩短为特征。在正常状态下不存在的两种未成熟形式,在贫血状态下被发现存在:嗜碱性成红细胞和具有嗜碱性细胞质的网织红细胞。这些形式介于骨髓嗜碱性成红细胞和红细胞之间。一些嗜碱性成红细胞出现在外周血中并在那里转化为嗜碱性网织红细胞。在嗜碱性成红细胞转化为嗜碱性网织红细胞的过程中,贫血动物的转录水平不会降低,且高于多染性成红细胞中的转录水平。总染色质凝聚并不反映转录水平的降低。