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[苯肼贫血大鼠骨髓和血细胞的增殖活性]

[Proliferative activity of bone marrow and blood cells in rats with phenylhydrazine anemia].

作者信息

Kul'minskaia A S, Gazarian K G

出版信息

Ontogenez. 1980;11(4):386-91.

PMID:7443181
Abstract

Anemia was induced in rats by phenylhydrazine. There were found in the blood basophil erythroblasts, macrocytes, both ortochromatic and polychromatophil and basophil reticulocytes (the number of which could attain 60%). The role of macrocytosis in the reaction of the organism is discussed. The mitotic activity of erythroid cells increased in the bone marrow. On the basis of comparison of hemopoiesis in mammals (rats) and birds, by the previous authors' publication, a suggestion is put forward to the effect that during evolution "reserve" erythropoiesis is preserved only in the forms with nucleate erythrocytes (birds) or in the cells which have not lost the nucleus (in the bone marrow of rats).

摘要

通过苯肼诱导大鼠产生贫血。在血液中发现了嗜碱性成红细胞、大红细胞、正色和多染性及嗜碱性网织红细胞(其数量可达60%)。讨论了大红细胞增多在机体反应中的作用。骨髓中红系细胞的有丝分裂活性增加。根据之前作者发表的关于哺乳动物(大鼠)和鸟类造血的比较,提出一种观点,即在进化过程中,“储备”造血仅保留在有核红细胞的形式(鸟类)或未失去细胞核的细胞中(大鼠骨髓中)。

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