[Changes in the nature of the differentiation of the erythroid stem cell in the bone marrow of mice as affected by the peritoneal cells of donors subjected to bloodletting].

The influence of the peritoneal cells unstimulated by an inflammatory agent (PCs) on the bone marrow erythropoiesis in the CBA mice was studied in the normal conditions and after the massive haemorrhage. The PCs obtained from the intact or anemic donors (2, 4 and 18 h after the haemorrhage) were introduced intraperitoneally into the intact syngeneic recipients. The massive haemorrhage induces a special type of differentiation of erythroid cells in bone marrow, "reserve erythropoiesis", which is characterized by a decrease, within four days, in the proliferation of basophilic proerythrocytes, stimulation of proliferation of polychromatophilic proerythrocytes and entry of oxyphilic proerythrocytes into mitosis. The transplantation of the PCs from the anemic donors induced the "reserve erythropoiesis" in the bone marrow of the recipients. The transplantation of the PCs from the intact donors did not induce the "reserve erythropoiesis" and appeared to inhibit erythropoiesis via lengthening the time of mitoses in polychromatophilic and basophilic proerythrocytes.