Mitskevich M S, Rumiantseva O N
Ontogenez. 1976;7(6):638-42.
Metopiron, hydrocortisone and dexamethazone are able to influence different links of the hypothalamo-hypohysial-adrenal system and induce the inhibition of glucocorticoid function. Changes in glycogen content in the adrenal gland and liver of rat foetuses under the effect of the drugs in question were studied. It was shown that metopiron exerted no marked influence on the level of glycogen in the adrenal gland and decreased 2.5 times that in the liver. On the contrary, hydrocortisone and dexamethazone increased the glycogen content 2 times in the adrenal gland and did not change that in the liver. The results obtained agree with the hypothesis on the relation between the glycogen level in the adrenal gland and the level of its hormonal activity and are considered as an additional proof of the functioning of hypothalamo-hypophysial-adrenal system during the last days of the rat prenatal development.
甲吡酮、氢化可的松和地塞米松能够影响下丘脑 - 垂体 - 肾上腺系统的不同环节，并诱导糖皮质激素功能的抑制。研究了上述药物作用下大鼠胎儿肾上腺和肝脏中糖原含量的变化。结果表明，甲吡酮对肾上腺中的糖原水平没有显著影响，而使肝脏中的糖原水平降低了2.5倍。相反，氢化可的松和地塞米松使肾上腺中的糖原含量增加了2倍，而对肝脏中的糖原含量没有影响。所得结果与肾上腺中糖原水平与其激素活性水平之间关系的假说相符，并被视为大鼠产前发育最后几天下丘脑 - 垂体 - 肾上腺系统功能的额外证据。
