Nosenko N D
Fiziol Zh (1994). 2008;54(3):22-7.
The protective effect of dexamethasone, a synthetic agonist of glucocorticoids, on the functional activity of hypothalamo-pituitary-adrenal system (HPAS) in adult offspring in both genders whose mothers were subject to immobilization stress in last trimester of pregnancy, has been studied. Dexamethasone treatment prior to stressing pregnant rats prevented the manifestations of injuring effect of prenatal stress on HPAS activity in adult male offspring. The post-stressor changes in hypothalamic noradrenaline content and corticosterone level in blood plasma, as well as GABAA and GABA, receptors activity, did not differ from normal indices. In prenatally stressed female rats no preventive effect of dexamethasone has been reported. The results of investigations suggest the pathogenetic role of increased production of glucocorticoids in mediating the mechanisms of prenatal stress effects in gender-related functional disorders of HPAS. They demonstrate the possibility of pharmacological prevention of some congenital forms of neuroendocrine pathology and determine the necessity of a gender approach when developing preventive strategies.
研究了糖皮质激素的合成激动剂地塞米松对妊娠晚期遭受固定应激的成年子代下丘脑-垂体-肾上腺系统（HPAS）功能活性的保护作用。在对怀孕大鼠施加应激之前给予地塞米松治疗，可预防产前应激对成年雄性子代HPAS活性的损伤作用表现。应激后下丘脑去甲肾上腺素含量和血浆皮质酮水平的变化，以及GABAA和GABA受体活性，均与正常指标无差异。在产前应激的雌性大鼠中，尚未报道地塞米松有预防作用。研究结果表明，糖皮质激素产生增加在介导产前应激对HPAS性别相关功能障碍影响机制中具有致病作用。它们证明了药物预防某些先天性神经内分泌病理形式的可能性，并确定了在制定预防策略时采用性别方法的必要性。
