Rumyantseva O N, Mitskevich M S
Sov J Dev Biol. 1975 Jul;5(4):327-35.
The functional state of the adrenals of rats during prenatal development was studied. The accumulation of glycogen in the adrenals and liver in 15.5-21.5-day old embryos was used as the index. The maximum glycogen concentration in the adrenals and the minimum in the liver were detected in 15.5-16.5-day embryos, i.e., before the adrenals had begun to produce glucocorticoids. A sharp decrease in glycogen in the adrenals was observed in 17.5-day embryos, and an appreciable accumulation in the liver in 18.5-day embryos, which coincides with the beginning of the glucocorticoid function. Decapitation and encephalectomy performed at an age of 17.5-19.5 days of development of the embryos, were invariably accompanied by a significant increase in the glycogen content in the adrenals and a decrease in its level in the liver in the case of investigation after two days. This indicates an active participation of the hypothalamo-pituitary system in the regulation of the adrenocortical function in the late days of embryonic development.
研究了大鼠产前发育过程中肾上腺的功能状态。以15.5 - 21.5日龄胚胎肾上腺和肝脏中糖原的积累作为指标。在15.5 - 16.5日龄胚胎中检测到肾上腺中糖原浓度最高，肝脏中糖原浓度最低，即肾上腺开始产生糖皮质激素之前。在17.5日龄胚胎中观察到肾上腺中糖原急剧减少，在18.5日龄胚胎中肝脏中有明显积累，这与糖皮质激素功能开始相吻合。在胚胎发育17.5 - 19.5日龄时进行断头和脑切除，在两天后的调查中，肾上腺中糖原含量总是显著增加，肝脏中糖原水平降低。这表明下丘脑 - 垂体系统在胚胎发育后期肾上腺皮质功能调节中起积极作用。
