Voĭtenko G A, Larionov V G
Farmakol Toksikol. 1976 Sep-Oct;39(5):622-5.
The experiment involved an investigation into the action of O,O-dimethyl-S-(N-methyl-carbomoilmethyl)-dithiophosphate (phosphamide), used at the level of the liminal dose (4 mg/kg) and in a concentration of 1.9 mg/m3, as compared with the effect of 1/2 of the liminal dose and 1/2 of the thereshold concentration. Both were simultaneously introduced into the organism of test albino rats for a period of 4 months and their complex action showed an intensification of the toxic effect. In evidence was also a more marked anticholinesterase action, a higher level of the insecticide in biological substrates and greater changes of hematological indices.
该实验涉及对O,O-二甲基-S-(N-甲基氨基甲酰甲基)二硫代磷酸酯（甲胺磷）作用的研究，其使用阈剂量水平（4毫克/千克）和浓度为1.9毫克/立方米，并与阈剂量的1/2和阈浓度的1/2的效果进行比较。将二者同时引入受试白化大鼠体内4个月，其综合作用显示出毒性作用增强。还证实存在更明显的抗胆碱酯酶作用、生物基质中杀虫剂水平更高以及血液学指标变化更大。
