Rees J A, Risdall P C
J Int Med Res. 1976;4(5):319-25. doi: 10.1177/030006057600400505.
This paper reports on the use of a single daily dose of dothiepin hydrochloride (Prothiaden). The results from a metabolism study using [14C] dothiepin were used to calculate the daily variations in blood levels after once daily and thrice daily dose regimes. A clinical study on the use of a single daily dose of 75 mg of dothiepin showed this type of regime to be well tolerated and efficacious in the treatment of 105 depressed patients in general practice. Compared to a thrice daily regime the once daily dose appeared to be more beneficial on symptomatic insomnia during the early treatment period.
本文报道了每日单次剂量使用盐酸多塞平（普罗替林）的情况。利用[14C]多塞平进行的代谢研究结果，用于计算每日单次和每日三次给药方案后血药浓度的每日变化。一项关于每日单次剂量使用75毫克多塞平的临床研究表明，这种给药方案在全科医疗中治疗105例抑郁症患者时耐受性良好且有效。与每日三次给药方案相比，每日单次剂量在治疗初期对症状性失眠似乎更有益。
