[抑制二磷酸腺苷诱导的血小板聚集作为评估某些肠杆菌产肠毒素能力的一种可能检测方法。初步研究]

[Inhibition of ADP-induced platelet aggregation as a possible test for evaluation of the enterotoxigenicity of some enterobacteria. Preliminary study].

作者信息

Fumarola D, Pasquetto N, Brandonisio O, Monno R, Miragliotta G

出版信息

G Batteriol Virol Immunol. 1976 Jul-Dec;69(7-12):234-43.

Abstract

Some culture filtrates or enterotoxin preparations from enterobacteria that activate the adenylate cyclase system (vibrio cholerae, LT fraction from escherichia coli and klebsiella pneumoniae, shigella dysenteriae type 1) exibit an inhibiting effect on ADP-induced platelet aggregation, while other enterotoxin preparations not effective on adenylate cyclase system, don't interfere with this model. The A. propose the platelet aggregation as cellular assay to detect enterotoxin fractions effective upon adenylate cyclase system.

摘要

一些来自激活腺苷酸环化酶系统的肠杆菌的培养滤液或肠毒素制剂（霍乱弧菌、大肠杆菌和肺炎克雷伯菌的LT组分、痢疾志贺菌1型）对ADP诱导的血小板聚集具有抑制作用，而其他对腺苷酸环化酶系统无效的肠毒素制剂则不干扰该模型。A.提出将血小板聚集作为细胞检测方法，以检测对腺苷酸环化酶系统有效的肠毒素组分。

相似文献

1

[Inhibition of ADP-induced platelet aggregation as a possible test for evaluation of the enterotoxigenicity of some enterobacteria. Preliminary study].[抑制二磷酸腺苷诱导的血小板聚集作为评估某些肠杆菌产肠毒素能力的一种可能检测方法。初步研究]

G Batteriol Virol Immunol. 1976 Jul-Dec;69(7-12):234-43.

2

[Possible use of the platelet as the cell system for the control of enteropathogenicity of E. coli and of other enterobacteria. Preliminary approach].[血小板作为控制大肠杆菌和其他肠道细菌肠道致病性的细胞系统的可能用途。初步探讨]

Boll Ist Sieroter Milan. 1976;55(5):436-42.

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4

[About employing platelets to determine enterotoxigenic activity of E. coli and others enterobacteria. Preliminary approach (author's transl)].[关于利用血小板测定大肠杆菌及其他肠道细菌的产肠毒素活性。初步方法（作者译）]

Quad Sclavo Diagn. 1977 Mar;13(1):53-66.

5

[Preliminary observations on the possible use of platelets as a cellular system in order to check the enteropathogenic activity of Escherichia coli and other enterobacteria (author's transl].关于将血小板用作细胞系统以检测大肠杆菌和其他肠道细菌肠道致病活性的初步观察（作者译）

Pathologica. 1977 Jan-Feb;69(987-988):65-75.

6

[Effect of cholera vibrio and Escherichia coli enterotoxins on human thrombocyte aggregation induced by adenosine diphosphate].

Vestn Akad Med Nauk SSSR. 1976(1):59-64.

7

Role of intracellular signaling events in ADP-induced platelet aggregation.细胞内信号事件在二磷酸腺苷诱导的血小板聚集中的作用。

Thromb Haemost. 1999 Oct;82(4):1322-6.

8

Activation of intestinal mucosal adenylate cyclase by Shigella dysenteriae I enterotoxin.痢疾志贺氏菌I型肠毒素对肠粘膜腺苷酸环化酶的激活作用。

Gastroenterology. 1976 Jun;70(6):1085-90.

9

Evidence that adenosine diphosphate can activate adenylate cyclase via conversion to adenosine in platelet-rich plasma containing magnesium.在含有镁的富血小板血浆中，二磷酸腺苷可通过转化为腺苷来激活腺苷酸环化酶的证据。

Thromb Haemost. 1998 Aug;80(2):321-5.

10

Activation of adenylate cyclase by heat-labile Escherichia coli enterotoxin. Evidence for ADP-ribosyltransferase activity similar to that of choleragen.不耐热的大肠杆菌肠毒素对腺苷酸环化酶的激活作用。存在与霍乱毒素类似的ADP-核糖基转移酶活性的证据。

J Clin Invest. 1978 Aug;62(2):281-5. doi: 10.1172/JCI109127.

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