El-Sokkary M B
Egypt J Bilharz. 1976;3(1):101-5.
The histological picture of the ventricle of frog's heart exposed to the action of Hycanthone in Ringer's solution in concentration of 1:1 was compared with that of the ventricle of frog's heart exposed to Ringer's solution devoid of the drug and with that of frog's heart exposed to Ringer's solution containing Hycanthone in concentration of 1:1 in addition to a soluble sodium salt of prednisolone hemisuccinate in concentration 1:1. It was found that the structure of the ventricle of the heart exposed to the action of Hycanthone in the presence of the soluble sodium salt of prednisolone hemisuccinate was close in pattern to the structure of the ventricle of the heart exposed to Ringer's solution alone, while the ventricle of the heart exposed to Hycanthone alone in Ringer's solution in concentration of 1:1 was different in that the muscle fibres swollen, the cytoplasm was paler with less marked striations, the nuclei were swollen and paler, the epicardial cells were swollen and the connective tissue pattern was distorted. This denoted that the morphological changes that occurred in response to Hycanthone in the presence of the soluble sodium salt of prednisolone hemisuccinate was less marked than those which occurred in its absence.
将浓度为1:1的海恩酮在任氏液中作用下的青蛙心室组织学图片，与暴露于不含该药物的任氏液中的青蛙心室组织学图片，以及暴露于除了浓度为1:1的氢化泼尼松半琥珀酸钠可溶性钠盐之外还含有浓度为1:1的海恩酮的任氏液中的青蛙心室组织学图片进行比较。结果发现，在氢化泼尼松半琥珀酸钠可溶性钠盐存在的情况下，暴露于海恩酮作用下的心脏心室结构在模式上与仅暴露于任氏液中的心脏心室结构相近，而在浓度为1:1的任氏液中单独暴露于海恩酮的心脏心室则不同，其肌纤维肿胀，细胞质颜色变浅，横纹不明显，细胞核肿胀且颜色变浅，心外膜细胞肿胀，结缔组织模式扭曲。这表明，在氢化泼尼松半琥珀酸钠可溶性钠盐存在的情况下，对海恩酮产生的形态学变化比不存在该钠盐时产生的变化不那么明显。
