El-Sokkary M B
Egypt J Bilharz. 1976;3(1):89-99.
The effects of the topical application of Dyphylline in concentrations of 1.0 mg/1.0 ml and 10 mg/1.0 ml Ringer's solution and 25 mg/1.0 ml, 0.065% NaCl solution (the content of ampoules in clinical use) were investigated on frog's heart in situ. Dyphylline in all of the above concentrations had a stimulatory effect on the frog's heart. Hycanthone methanesulphonate in concentration of 1.0 ml/1.0 ml when topically applied to the frog's heart had a depressant effect on both of the contractility and rhythmicity. The depressant effects of Hycanthone in concentration of 1:1 were compared before and after the topical application of Dyphylline in the above mentioned concentrations. It was found that Dyphylline in concentration of 1.0 mg/1.0 ml could partially antagonize the depressant effect of Hycanthone on the heart rate but not on the force of contraction. Dyphylline in concentration of 10 mg/1.0 ml could partially antagonize the depressant effects of Hycanthone on both of the heart rate and the force of contraction. Dyphylline in concentration of 25 mg/1.0 ml could completely antagonize the depressant effects of hycanthone on both of the heart rate and the force of contraction.
研究了将浓度为1.0毫克/1.0毫升和10毫克/1.0毫升的二羟丙茶碱林格氏溶液以及25毫克/1.0毫升、0.065%氯化钠溶液（临床使用安瓿中的含量）局部应用于蛙的原位心脏的效果。上述所有浓度的二羟丙茶碱对蛙心均有刺激作用。浓度为1.0毫升/1.0毫升的甲磺海蒽酮局部应用于蛙心时，对收缩性和节律性均有抑制作用。比较了上述浓度的二羟丙茶碱局部应用前后，1:1浓度的海蒽酮的抑制作用。发现浓度为1.0毫克/1.0毫升的二羟丙茶碱可部分拮抗海蒽酮对心率的抑制作用，但对收缩力无拮抗作用。浓度为10毫克/1.0毫升的二羟丙茶碱可部分拮抗海蒽酮对心率和收缩力的抑制作用。浓度为25毫克/1.0毫升的二羟丙茶碱可完全拮抗海蒽酮对心率和收缩力的抑制作用。
