Truhaut R, Ferrando R
Eur J Toxicol Environ Hyg. 1976;9(7 Suppl):413-22.
The authors report the underlying principles of the new methodological approach called "relay toxicity" which they proposed eight years ago for the toxicological evaluation of animal feed additives. They stress its value either as a possible criterion of rejection or as a criterion of acceptability. In the latter case, the limiting factor is the difficulty of applying an adequate safety factor when food products destined for human consumption and obtained from animals receiving the additives to be evaluated are administered to laboratory animals. Amongst the examples of the additives which have been subjected to toxicological evaluation using the authors' new method, the following are examined: as growth factor, carbadox, anabolising agents and, in particular, diethylstilboestrol, and steroids used as egglaying potentializers. The results obtained are discussed.
作者报告了他们八年前提出的名为“接力毒性”的新方法学方法的基本原理，该方法用于动物饲料添加剂的毒理学评估。他们强调其作为可能的拒绝标准或可接受性标准的价值。在后一种情况下，限制因素是当将源自从接受待评估添加剂的动物获得的供人类食用的食品喂给实验动物时，应用适当安全系数的困难。在已使用作者的新方法进行毒理学评估的添加剂示例中，研究了以下几种：作为生长因子的卡巴氧、同化剂，特别是己烯雌酚，以及用作产蛋促进剂的类固醇。对所得结果进行了讨论。
