Ferrando R, Truhaut R, Raynaud J P
Folia Vet Lat. 1977 Oct-Dec;7(4):333-40.
Relay toxicity is a new approach which permits an evaluation of the harmlessness of residues found in tissue, for the human consumer. Farm animals, swine for example, received high quantities of the additive over a long period. The swine were sacrificed without any withdrawal. Their meat and liver were added to the feed ration of laboratory animals to study the eventual problems of residue and metabolites. The following experiments were performed using carbadox:--Levels of carbadox up to 200 ppm were added to the swine ration (a maximum of 20 ppm is authorized). The meat and dehydrated liver were given in doses of 20% and 10% respectively, in the rat feed for 2 years or 3 generations.--The fresh meat, frozen then thawed at the time of use, was distributed to dogs daily for 7 1/2 years. No abnormalities were found, either in the growth of the animals or in their descendants. No abnormalities were observed macroscopically or microscopically after sacrifice. Relay toxicity gives high coefficients of security when the additive is used without withdrawal up to the time of sacrifice. This study demonstrated that the use of carbadox in swine doesn't present any disadvantage to the human consumer.
接力毒性是一种新方法，可用于评估人类消费者食用的组织中残留物质的无害性。农场动物，例如猪，长期摄入大量添加剂。猪在没有任何停药期的情况下被宰杀。它们的肉和肝脏被添加到实验动物的饲料中，以研究残留和代谢物的最终问题。使用卡巴氧进行了以下实验：——在猪的日粮中添加高达200 ppm的卡巴氧（法定最高限量为20 ppm）。肉和脱水肝脏分别以20%和10%的剂量添加到大鼠饲料中，持续2年或3代。——新鲜肉冷冻后在使用时解冻，每天喂给狗，持续7.5年。在动物及其后代的生长过程中均未发现异常。宰杀后在宏观或微观上均未观察到异常。当添加剂在宰杀前无停药期使用时，接力毒性具有很高的安全系数。这项研究表明，在猪中使用卡巴氧对人类消费者没有任何不利影响。
