Vorlaender K O
MMW Munch Med Wochenschr. 1979 Jan 5;121(1):21-4.
In principle the persistence of pathogens is favored by disturbances of the interplay between specific humoral and cellular defence mechanisms in the particular individual characteristic. Clinical secondary reactions in persistence of infection are in many cases not characterized by the infection as such but more decisively by the "terrain" which a particular organism encounters. This terrain is characterized by immunopathological secondary reactions which now become in turn the basis of the clinical secondary disease. In the individual case the manifestations are due to: acquired disturbances of immunotolerance; formation of neoantigens or induced autoimmune reactions; frequent immune complex reactions due to infectious or secondary antigens with corresponding antibody formation and complement activation.
原则上，病原体的持续存在受特定个体特征中特异性体液和细胞防御机制之间相互作用紊乱的影响。在许多情况下，感染持续存在时的临床继发反应并非以感染本身为特征，而是更决定性地取决于特定病原体所遭遇的“机体状况”。这种机体状况以免疫病理继发反应为特征，而这些反应反过来又成为临床继发病的基础。在个别病例中，临床表现归因于：获得性免疫耐受紊乱；新抗原的形成或诱导的自身免疫反应；由于感染性或继发性抗原以及相应抗体形成和补体激活而频繁发生的免疫复合物反应。
