Lewis E B
Nature. 1978 Dec 7;276(5688):565-70. doi: 10.1038/276565a0.
The bithorax gene complex in Drosophila contains a minimum of eight genes that seem to code for substances controlling levels of thoracic and abdominal development. The state of repression of at least four of these genes is controlled by cis-regulatory elements and a separate locus (Polycomb) seems to code for a repressor of the complex. The wild-type and mutant segmentation patterns are consistent with an antero-posterior gradient in repressor concentration along the embryo and a proximo-distal gradient along the chromosome in the affinities for repressor of each gene's cis-regulatory element.
果蝇中的双胸基因复合体至少包含八个基因，这些基因似乎编码控制胸腹部发育水平的物质。这些基因中至少有四个的抑制状态由顺式调控元件控制，一个单独的基因座（多梳基因座）似乎编码该复合体的一种阻遏物。野生型和突变型的体节模式与沿着胚胎的阻遏物浓度的前后梯度以及沿着染色体的每个基因的顺式调控元件对阻遏物的亲和力的近远梯度是一致的。
