Molinatti G M, Massara F, Isaia G C
Minerva Med. 1978 Oct 17;69(49):3373-86.
The identification and synthesis of thyrotrophin-releasing hormone (TRH) and luteinising hormone releasing hormone (LHRH) has widened our knowledge of hypothalamo-hypophyseal-thyroid and hypothalamo-hypophyseal-gonad diseases. More precisely, administration of these two releasing factors, by permitting the evaluation of pituitary TSH, LH, and FSH reserves, reveals otherwise undefinable changes in hypophyseal function. An account of the manner of execution and measurement, the administration route, and side-effects related to TRH and LHRH tests is followed by a description of the main diseases in which they offer the greatest degree of diagnostic assistance.
促甲状腺激素释放激素（TRH）和促黄体生成素释放激素（LHRH）的鉴定与合成拓宽了我们对下丘脑 - 垂体 - 甲状腺及下丘脑 - 垂体 - 性腺疾病的认识。更确切地说，通过给予这两种释放因子，能够评估垂体促甲状腺激素（TSH）、促黄体生成素（LH）和促卵泡生成素（FSH）的储备情况，从而揭示垂体功能中原本无法明确的变化。在介绍了TRH和LHRH试验的实施方式、测量方法、给药途径及相关副作用之后，将描述它们在其中提供最大程度诊断帮助的主要疾病。
