Tomov T, Ankov V
Vutr Boles. 1980;19(5):53-61.
The functional state of hypothalamus-hypophyseal-thyroid axis was investigated in 157 recruits and soldiers, aged from 17 to 26 with different forms of male hypogonadism: system of Kleinferter, male Turner, primary hypogonadism with recognized and unrecognized etiology, cryptorchism, anorchia, secondary hypogonadism and late puberty. Serum base level of TSH, T3, T4 were radioimmunologically determined as well as T3 binding with serum proteins. Single intravenous stimulation was performed with 200 mkg TRH and with 100 mkg LH-RH to groups of patients with various forms of male hypogonadism. Furthermore, the level of protein conjugated iodine (PCI) in serum was determined as well as J131 absorption by the thyroid gland and metabolism. Serum level of TSH, in male hypogonadism, was elevated with Kleifelter system and late puberty. Base level of T3 was reduced, of T4 -- elevated insecondary hypogonadism. T3 binding with serum proteins on all forms of the disease was within the norm. With the single venous TRH stimulation, the separate patients showed various responses to TSH. But in all cases, a tendency to elevation in the first several minutes after the stimulation was observed with a further stronger or poorer tendency to returning to the norm. In one patient with secondary hypogonadism an interrupted elevation of TSH was observed. The stimulation with thyrotropin-releasing hormone (TRH) gave no significant deviation in the level of T3 and T4 both in healthy subjects and patients. Single intravenous stimulation with luteinizing hormone-releasing hormone (LH-RH) induced no significant changes in the level of thyroid stimulating hormone (TSH), T3, T4 and T3 binding with serum proteins in healthy subjects and patients. Base values of PCI in male hypogonadism were with normal ranges, J131 absorption by the thyroid gland and metabolism showing a tendency to lower values.
对157名年龄在17至26岁之间、患有不同形式男性性腺功能减退的新兵和士兵的下丘脑 - 垂体 - 甲状腺轴功能状态进行了研究，这些形式包括克莱费尔特综合征、男性特纳综合征、病因已明确和未明确的原发性性腺功能减退、隐睾症、无睾症、继发性性腺功能减退和青春期延迟。采用放射免疫法测定血清促甲状腺激素（TSH）、三碘甲状腺原氨酸（T3）、甲状腺素（T4）的基础水平以及T3与血清蛋白的结合情况。对患有各种形式男性性腺功能减退的患者组，单次静脉注射200μg促甲状腺激素释放激素（TRH）和100μg促黄体生成素释放激素（LH - RH）进行刺激。此外，还测定了血清中蛋白结合碘（PCI）的水平以及甲状腺对碘 - 131的摄取和代谢情况。在男性性腺功能减退患者中，克莱费尔特综合征和青春期延迟患者的血清TSH水平升高。继发性性腺功能减退患者的T3基础水平降低，T4升高。在所有疾病形式中，T3与血清蛋白的结合均在正常范围内。单次静脉注射TRH刺激后，不同患者对TSH的反应各异。但在所有情况下，刺激后最初几分钟内均观察到TSH有升高趋势，随后恢复正常的趋势更强或更弱。在一名继发性性腺功能减退患者中，观察到TSH呈间断性升高。促甲状腺激素释放激素（TRH）刺激后，健康受试者和患者的T3和T4水平均无明显偏差。促黄体生成素释放激素（LH - RH）单次静脉注射刺激后，健康受试者和患者的促甲状腺激素（TSH）、T3、T4水平以及T3与血清蛋白的结合均无明显变化。男性性腺功能减退患者的PCI基础值在正常范围内，甲状腺对碘 - 131的摄取和代谢呈降低趋势。
