Moore E S, Chung E E, Cevallos E E, McMann B J
Pediatr Res. 1978 Nov;12(11):1066-9. doi: 10.1203/00006450-197811000-00008.
The purpose of this study was to investigate the possible role of diminished phosphate clearance by the fetal kidney in production of relative fetal hyperphosphatemia. Stimuli known to affect renal phosphate clearance in adults were investigated in young fetal lambs. Our studies confirm that the fetal lamb kidney responds to exogenous and endogenous parathyroid hormone (PTH) with inhibition of tubular phosphate reabsorption. Renal tubular phosphate reabsorption in the fetus is in part related to sodium reabsorption. These studies indicate that so-called "immaturity" of renal phosphate clearance in utero is not a significant factor in production of fetal hyperphosphatemia.
本研究的目的是探讨胎儿肾脏磷酸盐清除能力降低在胎儿相对性高磷血症产生过程中可能发挥的作用。我们在年轻的胎羊身上研究了已知会影响成年动物肾脏磷酸盐清除能力的刺激因素。我们的研究证实，胎羊肾脏对外源性和内源性甲状旁腺激素（PTH）作出反应，肾小管对磷酸盐的重吸收受到抑制。胎儿肾小管对磷酸盐的重吸收部分与钠的重吸收有关。这些研究表明，子宫内肾脏磷酸盐清除能力所谓的“不成熟”并非胎儿高磷血症产生的重要因素。
