Colin J
Nouv Presse Med. 1978 Sep 30;7(33):2949-53.
The range of treatment proposed for ocular herpes regularly widens. In addition to the harmful effects of the herpes virus itself, there are local immunological mechanisms which render the use of antiviral substances all the more difficult. Those currently available (5 iodo 2'deoxyuridine, vidarabine, trifluorothymidine) are certainly of the greatest value in superficial forms but have little effect upon deep seated stromal and uveal involvement. In addition, they are toxic to the corneal epithelium. At all events, they offer treatment during acute exacerbations and cannot prevent recurrences. Treatment should thus often consist of corticosteroids and antiviral agents in alternation and the solution is sometimes to be found in the combined use of these two substances. Surgery is above all indicated in the treatment of the sequelae of ocular herpes, the results of operations performed during acute phases being less definite.
针对眼部疱疹所提出的治疗范围正在不断扩大。除了疱疹病毒本身的有害影响外,还有局部免疫机制,这使得抗病毒药物的使用更加困难。目前可用的药物(5-碘-2'-脱氧尿苷、阿糖腺苷、三氟胸腺嘧啶)对于浅表型疱疹肯定具有极大价值,但对深部基质和葡萄膜受累几乎没有效果。此外,它们对角膜上皮有毒性。无论如何,它们仅在急性发作期提供治疗,无法预防复发。因此,治疗通常应交替使用皮质类固醇和抗病毒药物,有时可通过联合使用这两种药物找到解决方案。手术主要用于治疗眼部疱疹的后遗症,急性期进行手术的效果不太明确。