Grabner G, Jarisch R
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1979 Jul 2;211(1):85-93. doi: 10.1007/BF00414656.
Using a direct assay of leukocyte migration inhibitory factor (LMIF), cell-mediated immunity to herpes simplex virus (HSV) antigen was measured in patients who had primary and recurrent ocular HSV infections. Those with primary and recurrent epithelial disease had a significantly lower production of LMIF than a control population than had had no herpetic infection for at least a year or longer (P less than 0.001). On the contrary, patients with deep stromal involvement and anterior uveitis showed significant migration inhibition with HSV antigen, similar to the one found in the healthy control group. The clinical and possible therapeutic implications of thes findings are discussed.
采用白细胞迁移抑制因子（LMIF）直接检测法，对患有原发性和复发性眼部单纯疱疹病毒（HSV）感染的患者进行了针对HSV抗原的细胞介导免疫检测。患有原发性和复发性上皮疾病的患者产生的LMIF明显低于至少一年或更长时间未发生疱疹感染的对照人群（P小于0.001）。相反，深层基质受累和前葡萄膜炎患者对HSV抗原表现出明显的迁移抑制，类似于健康对照组的情况。本文讨论了这些发现的临床意义及可能的治疗意义。
