Virnik A D, Snejhko V A, Khomiakov K P
Polim Med. 1976;6(4):191-210.
The article reviews the papers on modifying the properties of drugs by their administration in the form of a mixture with polymers, or combination of the drugs and polymers using coordinative or ionic bonds. In many cases the combination of drugs and polymers by chemical means or preparation of a mixture of drugs and polymers prolongs and increases the effectivity of drugs, increases their solubility, decreases their toxicity, and modifies their distribution in the organs.
本文综述了有关通过将药物与聚合物混合给药，或利用配位键或离子键将药物与聚合物结合的方式来改变药物性质的论文。在许多情况下，通过化学方法将药物与聚合物结合或制备药物与聚合物的混合物，可延长并提高药物的有效性，增加其溶解度，降低其毒性，并改变其在器官中的分布。
