Virnik A D, Snezhko V A, Khomiakov K P
Polim Med. 1977;7(1):27-55.
In the second part of the paper there have been discussed the works on modification of drugs properties when coupled with polymers in terms of covalent links. It was proved on a number of cases that chemical bonds of specified drugs and polymers allows to increase the durability and effective action of these remedies, to decrease the toxicity, to increase the solubility and immunity against ferments and, moreover, enable the advantageous disposal of these substances in particular organs.
在论文的第二部分,讨论了通过共价键与聚合物结合来改变药物性质的相关研究。在许多案例中已证明,特定药物与聚合物之间的化学键能够提高这些药物的稳定性和疗效,降低毒性,增加溶解度以及对酶的耐受性,此外,还能使这些物质在特定器官中得到有利处置。