尼古丁-11C：动物体内的合成与分布动力学
Nicotine-11C: synthesis and distribution kinetics in animals.
作者信息
Mazière M, Comar D, Marazano C, Berger G
出版信息
Eur J Nucl Med. 1976 Dec 30;1(4):255-8. doi: 10.1007/BF00252173.
PMID:1031371
Abstract
In order to study "in vivo" the distribution kinetics of (-)-nicotine in animals, this molecule was labeled with carbon-11. Two synthesis methods are described. Immediately after intravenous administration of (-)-nicotine-methyl-11C in rabbits the gamma-camera shows a strong radioactivity build-up in the brain and kidneys. The biological interest of this carbon-11 labeled molecule is discussed.
摘要
为了在动物体内研究（-）-尼古丁的分布动力学，该分子用碳-11进行了标记。描述了两种合成方法。给兔子静脉注射（-）-尼古丁-甲基-11C后，γ相机立即显示出大脑和肾脏中有强烈的放射性积聚。讨论了这种碳-11标记分子的生物学意义。
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