The metabolism of [14C] nicotine in the cat.
作者信息
Turner D M
出版信息
Biochem J. 1969 Dec;115(5):889-96. doi: 10.1042/bj1150889.
Abstract
The metabolism of [2'-(14)C]nicotine given as an intravenous injection in small doses to anaesthetized and unanaesthetized cats has been studied. A method is described for the quantitative determination of [(14)C]nicotine and [(14)C]cotinine in tissues and body fluids. Nanogram amounts of these compounds have been detected. After a single dose of 40mug. of [(14)C]nicotine/kg., 55% of the injected radioactivity was excreted in the urine within 24hr., but only 1% of this radioactivity was unchanged nicotine. [(14)C]Nicotine is metabolized extremely rapidly, [(14)C]cotinine appearing in the blood within 2.5min. of intravenous injection. [(14)C]Nicotine accumulates rapidly in the brain and 15min. after injection 90% of the radioactivity still represents [(14)C]nicotine. Metabolites of [(14)C]nicotine have been identified in liver and urine extracts. [(14)C]Nicotine-1'-oxide has been detected in both liver and urine.
摘要
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1
Excretion and tissue distribution studies on radioactive nicotine.
J Pharmacol Exp Ther. 1951 Oct;103(2):209-14.
2
Enzymatic pathway for the formation of cotinine, a major metabolite of nicotine in rabbit liver.
J Pharmacol Exp Ther. 1960 May;129:94-100.
3
[ENZYME CHEMISTRY STUDIES ON NICOTINE DEGRADATION IN RABBIT LIVER].
Biochem Z. 1964 Aug 11;340:326-36.
4
RADIOASSAY OF THIN-LAYER CHROMATOGRAMS: A HIGH-RESOLUTION ZONAL SCRAPER FOR QUANTITATIVE C14 AND H3 SCANNING OF THIN-LAYER CHROMATOGRAMS.
Anal Biochem. 1964 Oct;9:183-96. doi: 10.1016/0003-2697(64)90102-2.
5
METABOLISM OF NICOTINE IN MOUSE TISSUE SLICES.
Acta Physiol Scand. 1964 Aug;61:380-92.
6
FORMATION OF NORNICOTINE AND OTHER METABOLITES FROM NICOTINE IN VITRO AND IN VIVO.
Can J Biochem. 1964 Apr;42:435-42. doi: 10.1139/o64-051.
7
DISPOSITION AND FATE OF (--)-COTININE-H3 IN THE MOUSE.
J Pharmacol Exp Ther. 1964 Mar;143:301-8.
8
STUDIES ON THE EXCRETION AND DISTRIBUTION OF RADIOACTIVE NICOTINE AND SOME EVIDENCE ON THE URINARY METABOLITES.
Arch Int Pharmacodyn Ther. 1963 Sep 1;145:123-36.
9
The accumulation and metabolism of C14-labelled nicotine in the brain of mice and cats.
Acta Physiol Scand. 1962 Nov-Dec;56:249-57. doi: 10.1111/j.1748-1716.1962.tb02502.x.
10
Formation of metabolites from nicotine by a rabbit liver preparation.
J Pharmacol Exp Ther. 1963 Jun;140:269-77.
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