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低剂量胰岛素——高渗性非酮症昏迷与糖尿病酮症酸中毒的比较(作者译)

[Low doses of insulin--comparison between hyperosmolar nonketotic coma and diabetic ketoacidosis (author's transl)].

作者信息

Pelosi R M, Reis L C

出版信息

Rev Bras Pesqui Med Biol. 1978 Oct;11(4-5):249-58.

PMID:103144
Abstract

The authors present a comparison between the results achieved in the treatment of 11 cases of nonketotic hyperosmolar "coma" and 13 cases of diabetic ketoacidosis using low doses of intramuscular insulin hourly. Surprisingly both, larger amounts of insulin and longer periods were needed to compensate the metabolic disturbance of the nonketotic hyperosmolar "coma" cases when compared to the ketoacidosis ones. The data obtained in this study suggest a possible direct relationship between the initial urea levels and the total amount of insulin needed to reduce the initial glycemia to a normal glycemic level.

摘要

作者对每小时使用低剂量肌肉注射胰岛素治疗11例非酮症高渗性“昏迷”患者和13例糖尿病酮症酸中毒患者的结果进行了比较。令人惊讶的是,与酮症酸中毒患者相比,非酮症高渗性“昏迷”患者需要更多的胰岛素和更长的时间来补偿代谢紊乱。本研究获得的数据表明,初始尿素水平与将初始血糖降至正常血糖水平所需的胰岛素总量之间可能存在直接关系。

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