Khmelnitsky O K, Kotchubey N M
Acta Morphol Acad Sci Hung. 1976;24(1-2):1-9.
The histological and biochemical changes in adrenal function has been studied in 50 male cats with circulatory failure. The adrenal glands were examined by morphometric, histochemical and histoenzymological methods after a preliminarily study of the histoenzymological profile of the adrenal glands in intact animals. Five hours after hypotension induced by intravenous injection of trimethaphan and 5 hours after a single massive bleeding, a decrease in adrenal function was observed. Adrenal insufficiency especially of the glucocorticoid release in the course of acute circulatory failure can be considered as a peculiar adaptation of the organism to preserve its life. The demonstrated decrease of adrenal function in the first hours of hypoxia may help in planning hormonal therapy under suitable conditions.
对50只患有循环衰竭的雄性猫的肾上腺功能的组织学和生化变化进行了研究。在对完整动物肾上腺的组织酶学特征进行初步研究后，通过形态计量学、组织化学和组织酶学方法对肾上腺进行了检查。静脉注射三甲噻方诱导低血压5小时后以及单次大量出血5小时后，观察到肾上腺功能下降。在急性循环衰竭过程中，肾上腺功能不全，尤其是糖皮质激素释放不足，可被视为机体为维持生命而进行的一种特殊适应。所证实的缺氧最初几小时内肾上腺功能下降，可能有助于在适当条件下规划激素治疗。
