Heil T, Mattes P, Raptis S
Langenbecks Arch Chir. 1976;Suppl:178-83.
The influence of gastrin and somatostatin on the lower esophageal sphincter was investigated in 10 metabolically healthy volunteers and one patient with Zollinger-Ellison syndrome. It could be shown that only unphysiologically high concentrations of gastrin produced a rise in pressure in the lower esophageal sphincter, while somatostatin has neither an effect on the lower esophageal sphincter pressure, nor is it able to inhibit the pharmacologic effect of exogeneous gastrin administration. The results emphasize that gastrin and somatostatin have no influence on the tone of the lower esophageal sphincter.
在10名代谢健康的志愿者和1名卓-艾综合征患者中研究了胃泌素和生长抑素对食管下括约肌的影响。结果表明，只有非生理性的高浓度胃泌素会使食管下括约肌压力升高，而生长抑素对食管下括约肌压力既无影响，也不能抑制外源性给予胃泌素的药理作用。这些结果强调胃泌素和生长抑素对食管下括约肌张力没有影响。
