Reyes C V, Jensen J D, Graham G
Cytology Section, Veterans Affairs Hospital, Hines, Illinois, USA.
Diagn Cytopathol. 1999 May;20(5):257-60. doi: 10.1002/(sici)1097-0339(199905)20:5<257::aid-dc2>3.0.co;2-e.
During a 10-yr period, 128 consecutive cases of pulmonary adenocarcinoma of varying differentiation were diagnosed with percutaneous fine-needle aspiration biopsy. Sediments from the needle and syringe washings with 3% glutaraldehyde were obtained and processed for electron microscopic evaluation in 73 cases. Our results showed three types of adenocarcinoma: 62 cases of nonciliated bronchiolar cell origin, 6 cases of bronchioloalveolar cell origin, and 3 cases of mucous cell origin. In addition, there was an example of combined adenosquamous carcinoma and an instance of amphicrine carcinoma. Our study provided a more precise definition of the cytologic diagnosis and insight into the heterogeneity of lung adenocarcinoma. However, prognostic differences between cell types of lung adenocarcinoma were not observed.
在10年期间，通过经皮细针穿刺活检诊断出128例连续的不同分化程度的肺腺癌病例。对73例病例获取了针吸物及用3%戊二醛冲洗注射器后的沉淀物，并进行处理以用于电子显微镜评估。我们的结果显示有三种类型的腺癌：62例起源于无纤毛细支气管细胞，6例起源于细支气管肺泡细胞，3例起源于黏液细胞。此外，有1例腺鳞癌合并病例和1例两性癌病例。我们的研究对肺腺癌的细胞学诊断提供了更精确的定义，并深入了解了其异质性。然而，未观察到肺腺癌不同细胞类型之间的预后差异。
